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      Cognitive deficits and associated neurological complications in individuals with Down's syndrome

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      The Lancet Neurology
      Elsevier BV

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          Abstract

          Improvements in medical interventions for people with Down's syndrome have led to a substantial increase in their longevity. Diagnosis and treatment of neurological complications are important in maintaining optimal cognitive functioning. The cognitive phenotype in Down's syndrome is characterised by impairments in morphosyntax, verbal short-term memory, and explicit long-term memory. However, visuospatial short-term memory, associative learning, and implicit long-term memory functions are preserved. Seizures are associated with cognitive decline and seem to cause additional decline in cognitive functioning, particularly in people with Down's syndrome and comorbid disorders such as autism. Vision and hearing disorders as well as hypothyroidism can negatively impact cognitive functioning in people with Down's syndrome. Dementia that resembles Alzheimer's disease is common in adults with Down's syndrome. Early-onset dementia in adults with Down's syndrome does not seem to be associated with atherosclerotic complications. Copyright 2010 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          The Lancet Neurology
          The Lancet Neurology
          Elsevier BV
          14744422
          June 2010
          June 2010
          : 9
          : 6
          : 623-633
          Article
          10.1016/S1474-4422(10)70112-5
          20494326
          c21c5bde-19a7-4421-8c17-c2b9f7b72a32
          © 2010

          https://www.elsevier.com/tdm/userlicense/1.0/

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