Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis.

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Abstract

To investigate the specific role of Frizzled-related protein (FRZB) and Secreted frizzled-related protein 1 (SFRP1) in the onset and progression of Osteoarthritis (OA) using Frzb(-/-) and Sfrp1(-/-) mice in the destabilization of medial meniscus model (DMM), a slowly progressing model of OA. Secreted frizzled-related proteins (SFRPs) were identified as secreted Wingless-type (Wnt) antagonists. The Wnt signaling cascade is a major regulator in cartilage development, homeostasis and degeneration.

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Journal

Journal ID (iso-abbrev): Osteoarthr. Cartil.

Title: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society

ISSN (Electronic): 1522-9653

ISSN (Print): 1063-4584

Publication date (Electronic): Feb 2015

Volume: 23

Issue: 2

Affiliations

[1 ] Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Belgium. Electronic address: Sarah.Thysen@med.kuleuven.be.

[2 ] Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Belgium; Division of Rheumatology, University Hospitals Leuven, Belgium. Electronic address: Frank.Luyten@uz.kuleuven.be.

[3 ] Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Belgium; Division of Rheumatology, University Hospitals Leuven, Belgium. Electronic address: Rik.Lories@uz.kuleuven.be.

Article

Publisher Item ID: S1063-4584(14)01307-7

DOI: 10.1016/j.joca.2014.10.010

PubMed ID: 25450854

SO-VID: c22557f8-6440-45b3-938f-a5fea98ba262

History

Keywords: Cartilage,FRZB,Osteoarthritis,SFRP,Subchondral bone,Wnt

Data availability:

Keywords: Cartilage, FRZB, Osteoarthritis, SFRP, Subchondral bone, Wnt

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