111
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.

      1 ,
      Nature reviews. Neuroscience
      Springer Science and Business Media LLC

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The loss of control over drug intake that occurs in addiction was initially believed to result from disruption of subcortical reward circuits. However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order executive function (for example, self-control, salience attribution and awareness). This Review focuses on functional neuroimaging studies conducted in the past decade that have expanded our understanding of the involvement of the PFC in drug addiction. Disruption of the PFC in addiction underlies not only compulsive drug taking but also accounts for the disadvantageous behaviours that are associated with addiction and the erosion of free will.

          Related collections

          Author and article information

          Journal
          Nat Rev Neurosci
          Nature reviews. Neuroscience
          Springer Science and Business Media LLC
          1471-0048
          1471-003X
          Oct 20 2011
          : 12
          : 11
          Affiliations
          [1 ] Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. rgoldstein@bnl.gov
          Article
          nrn3119 NIHMS408806
          10.1038/nrn3119
          3462342
          22011681
          c22c19d2-4360-4c58-9fca-91f642bb1a58
          History

          Comments

          Comment on this article