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A locally advanced breast cancer with difficult differential diagnosis of carcinosarcoma and atypical medullary carcinoma, which had poor response to adriamycin- and taxane-based neoadjuvant chemotherapy: a case report.

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      Abstract

      Atypical medullary carcinomas and carcinosarcoma have unique histopathological features. Here we present a case with a breast malignancy that had pathological characteristics of both. A 54-year old patient with a malignant breast mass received 6 cycles of adriamycin-based chemotherapy, followed by 3 cycles of paclitaxel monotherapy, and had a poor clinical response to treatment. A modified radical mastectomy was performed. The pathological diagnosis was complicated by an inability to distinguish between atypical medullary carcinoma and carcinosarcoma. The findings included a tumor that was well-circumscribed, high grade and a syncytial growth pattern as well as biphasic sarcomatous and carcinomatous characteristics. In conclusion, atypical medullary carcinoma and carcinosarcoma of the breast have entirely different prognoses and should be managed differently. Both should be treated by surgical resection, and additional therapy should be considered based on the cancer with the poorer prognosis.

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      Author and article information

      Affiliations
      [1 ] Department of Internal Medicine, Yonsei Cancer Center, Seoul, Korea.
      Journal
      Cancer Res Treat
      Cancer research and treatment : official journal of Korean Cancer Association
      Korean Cancer Association
      1598-2998
      1598-2998
      Sep 2007
      : 39
      : 3
      19746221
      10.4143/crt.2007.39.3.134
      2739326

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