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      Growing roles for the mTOR pathway.

      1 , ,
      Current opinion in cell biology
      Elsevier BV

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          Abstract

          The mammalian TOR (mTOR) pathway is a key regulator of cell growth and proliferation and increasing evidence suggests that its deregulation is associated with human diseases, including cancer and diabetes. The mTOR pathway integrates signals from nutrients, energy status and growth factors to regulate many processes, including autophagy, ribosome biogenesis and metabolism. Recent work identifying two structurally and functionally distinct mTOR-containing multiprotein complexes and TSC1/2, rheb, and AMPK as upstream regulators of mTOR is beginning to reveal how mTOR can sense diverse signals and produce a myriad of responses.

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          Author and article information

          Journal
          Curr Opin Cell Biol
          Current opinion in cell biology
          Elsevier BV
          0955-0674
          0955-0674
          Dec 2005
          : 17
          : 6
          Affiliations
          [1 ] Whitehead Institute, MIT Department of Biology, 9 Cambridge Center, Cambridge, Massachussetts 02142, USA.
          Article
          S0955-0674(05)00148-1
          10.1016/j.ceb.2005.09.009
          16226444
          c23d7430-2c10-4c11-8dca-7acfd61b61b6
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