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X-linked agammaglobulinemia
Surjit Singh ,
Amit Rawat ,
Deepti Suri ,
Anju Gupta ,
Ravinder Garg ,
Biman Saikia ,
Ranjana Walker Minz ,
Shobha Sehgal ,
Koon-Wing Chan ,
Yu Lung Lau ,
Chikako Kamae ,
Kenichi Honma ,
Noriko Nakagawa ,
Kohsuke Imai ,
Shigeaki Nonoyama ,
Koichi Oshima ,
Noriko Mitsuiki ,
Osamu Ohara
October 2016
October 2016
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Abstract
X-linked agammaglobulinemia (XLA) is an X-linked genetic defect in maturation of B
lymphocytes that results in the absence of B lymphocytes in the peripheral blood and
profound hypogammaglobulinemia. It is caused by a mutation in the BTK gene located
on the X chromosome. There are no large series describing XLA from the developing
world.