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      Statins enhance rotator cuff healing by stimulating the COX2/PGE2/EP4 pathway: an in vivo and in vitro study.

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          Abstract

          Statins are lipid-lowering drugs with many beneficial pleiotropic effects. Cyclooxygenase (COX2) selective inhibitors that are commonly prescribed in orthopaedic patients may effect healing. Evidence indicates that statins stimulate COX2 activity.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Am J Sports Med
          Title: The American journal of sports medicine
          ISSN (Electronic): 1552-3365
          ISSN (Print): 0363-5465
          Publication date (Electronic): Dec 2014
          Volume: 42
          Issue: 12
          Affiliations
          [1 ] Shoulder Unit, Orthopedic Surgery Division, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Bone Research Laboratory, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
          [2 ] Bone Research Laboratory, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
          [3 ] Shoulder Unit, Orthopedic Surgery Division, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
          [4 ] Biomechanics Laboratory, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
          [5 ] Shoulder Unit, Orthopedic Surgery Division, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel dremaman@gmail.com.
          Article
          Publisher Item ID: 0363546514545856
          DOI: 10.1177/0363546514545856
          PubMed ID: 25184246
          SO-VID: c24cbc38-dccc-4401-8863-8fe20f6f5127
          Copyright © © 2014 The Author(s).
          History

          Keywords: COX2,EP4,PGE2,acute inflammatory phase,rotator cuff,statins,tendon healing
          Data availability:
          Keywords: COX2, EP4, PGE2, acute inflammatory phase, rotator cuff, statins, tendon healing

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