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      Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region

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          Abstract

          The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associated with reduced risk of ZIKV infection and symptoms. The landscape of ZIKV immunity that now exists may affect the risk for future transmission.

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          Author and article information

          Journal
          Science
          Science
          American Association for the Advancement of Science (AAAS)
          0036-8075
          1095-9203
          February 07 2019
          February 08 2019
          February 07 2019
          February 08 2019
          : 363
          : 6427
          : 607-610
          Article
          10.1126/science.aav6618
          8221194
          30733412
          c25709e6-cffe-47ca-b8e7-28be2286f413
          © 2019

          http://www.sciencemag.org/about/science-licenses-journal-article-reuse

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