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      Prognostic value of variables derived from the six-minute walk test in patients with COPD: Results from the ECLIPSE study.

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          Abstract

          In addition to the six-min walk distance (6 MWD), other six-min walk test (6 MWT) derived variables, such as mean walk-speed (6MWSpeed), 6-min walk-work (6 MWW), distance-saturation product (DSP), exercise-induced oxygen desaturation (EID), and unintended stops may be useful for the prediction of mortality and hospitalization in patients with chronic obstructive pulmonary disease (COPD). We studied the association between 6 MWT-derived variables and mortality as well as hospitalization in COPD patients and compared it with the BODE index. A three-year prospective study (ECLIPSE) to evaluate the prognostic value of 6 MWT-derived variables in 2010 COPD patients. Cox's proportional-hazard regressions were performed to estimate 3-year mortality and hospitalization. During the follow-up, 193 subjects died and 622 were hospitalized. An adjusted Cox's regression model of hazard ratio [HR] for impaired 6 MWT-derived variables was significant referring to: mortality (6 MWD ≤334 m [2.30], 6MWSpeed ≤0.9 m/sec [2.15], 6 MWW ≤20000 m kg [2.17], DSP ≤290 m% [2.70], EID ≤88% [1.75], unintended stops [1.99]; and hospitalization (6 MWW ≤27000 m kg [1.23], EID ≤88% [1.25], BODE index ≥3 points [1.40]; all p ≤ 0.05). The 6 MWT-derived variables have an additional predictive value of mortality in patients with COPD. The 6 MWW, EID and the BODE index refine the prognosis of hospitalization.

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          Author and article information

          Journal
          Respir Med
          Respiratory medicine
          Elsevier BV
          1532-3064
          0954-6111
          Sep 2015
          : 109
          : 9
          Affiliations
          [1 ] Department of Research and Education; CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands. Electronic address: vasilisandrianopoulos@ciro-horn.nl.
          [2 ] Department of Research and Education; CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands; Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands.
          [3 ] Department of Respiratory Medicine, School of Clinical Science, University of Liverpool, United Kingdom.
          [4 ] Department of Research and Education; CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.
          [5 ] Department of Clinical Science, University of Bergen, Bergen, Norway.
          [6 ] Thorax Institute, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES, Barcelona, Spain.
          [7 ] University of Edinburgh, Medical Research Council Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, United Kingdom.
          [8 ] Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
          [9 ] GSK Research and Development, King of Prussia, Philadelphia, PA, USA.
          [10 ] Department of Physical Education and Sport Sciences, National and Kapodistrian University of Athens, Greece.
          [11 ] Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark; Respiratory and Allergy Research Group, Manchester Academic Health Science Center, University of Manchester, Manchester, UK.
          [12 ] Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
          [13 ] Department of Research and Education; CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands; REVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.
          Article
          S0954-6111(15)30016-0
          10.1016/j.rmed.2015.06.013
          26143282
          c2580a0e-477d-4b5b-9302-0fb7ad858a92
          History

          COPD,Exercise physiology,Exercise testing,Hospitalization,Mortality,Prognostic markers

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