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      Older-age onset of Kimura’s disease

      case-report

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          Abstract

          A 60-year-old man was admitted to our hospital with bilateral post auricular masses, first noticed 1 year earlier. Blood tests showed eosinophilia and high immunoglobulin E (IgE) levels, and cervical computed tomography showed 10-mm soft tissue masses with scattered lymphadenopathy. The tumors showed intermediate and high signal intensity on T1- and T2-weighted cervical magnetic resonance imaging, respectively. After mass resection, the tumors were diagnosed as Kimura’s disease (KD). Generally, KD affects young men; however, even in older patients, KD should be included as a differential diagnosis for head and neck tumors in patients with eosinophilia and high IgE.

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          Most cited references38

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          Kimura disease: review of the literature.

          S-C Pan, D. Xu, C Miao … (2008)
          Kimura disease (KD) is a rare, chronic inflammatory disease of unknown cause and is characterized by painless s.c. swellings and lymphadenopathy commonly affecting the head and neck region. Much therapeutics has been used to treat KD, but is not satisfactory because of frequent relapse. Imatinib has been reported previously to be useful for treatment of hypereosinophilic syndrome and may work by selectively blocking protein-tyrosine kinases, such as platelet-derived growth factor receptor, and c-Kit. We carried out immunohistochemical examination of platelet-derived growth factor receptor-alpha and c-Kit in tissues from patients with KD. The results were positive and suggested that Imatinib might be an effective drug for the treatment of the disease. We have also briefly reviewed the epidemiology, aetiology, clinical manifestations, laboratory and pathological examinations, differential diagnoses, treatment and prognosis of KD in this manuscript.
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            Kimura disease: CT and MR imaging findings.

            S.-W. Park, H-J Kim, K Sung … (2012)
            KD is a rare chronic inflammatory disorder of unknown etiology. The purpose of this study was to evaluate the CT and MR imaging findings of KD in the head and neck.
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              The clinicopathological characteristics of Kimura disease in Chinese patients.

              Xuehan Zhang, Yang Jiao (2019)
              Kimura disease (KD) is a rare idiopathic inflammatory disorder of unknown etiology. Unusual presentations of KD might cause diagnostic difficulty or be misdiagnosed as malignancy if clinical suspicion is insufficiently high. Here, we aimed to determine the clinicopathological features of Chinese KD patients to reveal further insights into the natural history and treatment of this disease.
              Article 0 comments Cited 16 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Eiichi Kakehi:
                ORCID: https://orcid.org/0000-0002-4556-8412
                Kazuhiko Kotani
                Tsubasa Yoshida
                Tsubasa Nakai
                Shigehisa Sakurai
                Akane Hirotani
                Kaduyo Simizu
                Takafumi Nozaki
                Keisuke Shoji
                Seiji Adachi
                Masami Matsumura
                Journal
                Journal ID (nlm-ta): Ther Adv Hematol
                Journal ID (iso-abbrev): Ther Adv Hematol
                Journal ID (publisher-id): TAH
                Journal ID (hwp): sptah
                Title: Therapeutic Advances in Hematology
                Publisher: SAGE Publications (Sage UK: London, England )
                ISSN (Print): 2040-6207
                ISSN (Electronic): 2040-6215
                Publication date (Electronic): 13 October 2020
                Publication date Collection: 2020
                Volume: 11
                Electronic Location Identifier: 2040620720962596
                Affiliations
                [1-2040620720962596]Department of General Medicine, Tottori Municipal Hospital 1-1 Matoba, Tottori-City, Tottori 680-8501, Japan
                [2-2040620720962596]Center for Community Medicine, Jichi Medical University, Shimotsuke-City, Tochigi, Japan
                [3-2040620720962596]Department of General Medicine, Tottori Municipal Hospital, Tottori-City, Tottori, Japan
                [4-2040620720962596]Department of General Medicine, Tottori Municipal Hospital, Tottori-City, Tottori, Japan
                [5-2040620720962596]Department of General Medicine, Tottori Municipal Hospital, Tottori-City, Tottori, Japan
                [6-2040620720962596]Department of General Medicine, Tottori Municipal Hospital, Tottori-City, Tottori, Japan
                [7-2040620720962596]Department of General Medicine, Tottori Municipal Hospital, Tottori-City, Tottori, Japan
                [8-2040620720962596]Department of General Medicine, Tottori Municipal Hospital, Tottori-City, Tottori, Japan
                [9-2040620720962596]Department of General Medicine, Tottori Municipal Hospital, Tottori-City, Tottori, Japan
                [10-2040620720962596]Department of General Medicine, Tottori Municipal Hospital, Tottori-City, Tottori, Japan
                [11-2040620720962596]Center for Community Medicine, Jichi Medical University, Shimotsuke-City, Tochigi, Japan
                Author notes
                Author information
                https://orcid.org/0000-0002-4556-8412
                Article
                Publisher ID: 10.1177_2040620720962596
                DOI: 10.1177/2040620720962596
                PMC ID: 7570770
                SO-VID: c29b3505-e848-4f27-8d94-0eb9cc86f847
                Copyright © © The Author(s), 2020
                License:

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                History
                Date received : 10 April 2020
                Date accepted : 7 September 2020
                Categories
                Subject: Case Report
                Custom metadata
                cover-date January-December 2020
                typesetter ts1

                ScienceOpen disciplines: Hematology
                Keywords: eosinophilia,high immunoglobulin e,kimura’s disease,older patients
                Data availability:
                ScienceOpen disciplines: Hematology
                Keywords: eosinophilia, high immunoglobulin e, kimura’s disease, older patients

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