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      The extended protein kinase C superfamily.

      1 ,
      The Biochemical journal
      Portland Press Ltd.

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          Abstract

          Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in a multitude of cellular processes, ranging from control of fundamental cell autonomous activities, such as proliferation, to more organismal functions, such as memory. However, understanding of mammalian PKC signalling systems is complicated by the large number of family members. Significant progress has been made through studies based on comparative analysis, which have defined a number of regulatory elements in PKCs which confer specific location and activation signals to each isotype. Further studies on simple organisms have shown that PKC signalling paradigms are conserved through evolution from yeast to humans, underscoring the importance of this family in cellular signalling and giving novel insights into PKC function in complex mammalian systems.

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          Author and article information

          Journal
          Biochem J
          The Biochemical journal
          Portland Press Ltd.
          0264-6021
          0264-6021
          Jun 01 1998
          : 332 ( Pt 2)
          Affiliations
          [1 ] Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
          Article
          10.1042/bj3320281
          1219479
          9601053
          c2a4a39f-a981-497c-a9dc-212982a0e470
          History

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