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      The human cytomegalovirus non-coding Beta2.7 RNA as a novel therapeutic for Parkinson's disease--Translational research with no translation.

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          Abstract

          Human cytomegalovirus (HCMV) encodes abundant numbers of microRNAs (miRNAs) and other non-coding RNAs (ncRNAs) whose functions are presently under intense investigation. In this chapter, we discuss the function of one of the more well characterised virus-encoded ncRNAs, derived from the viral major early gene (Beta2.7). This RNA plays an anti-apoptotic role during infection by directly interacting with mitochondrial complex I to help maintain high levels of ATP production and by preventing the stress induced re-localisation of retinoid/interferon-induced mortality-19 protein, GRIM-19. We then go on to describe how an 800 nucleotide sub-domain of the Beta2.7 transcript, p137, has been exploited in the development of a novel therapeutic for the treatment of Parkinson's disease.

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          Author and article information

          Journal
          Virus Res.
          Virus research
          Elsevier BV
          1872-7492
          0168-1702
          Jan 02 2016
          : 212
          Affiliations
          [1 ] Department of Medicine, Addenbrooke's Hospital, Hills Road, England CB2 0QQ UK. Electronic address: elp27@cam.ac.uk.
          [2 ] Department of Neurology, Addenbrooke's Hospital, Hills Road, England CB2 0QQ, UK.
          [3 ] Department of Medicine, Addenbrooke's Hospital, Hills Road, England CB2 0QQ UK. Electronic address: js152@cam.ac.uk.
          Article
          S0168-1702(15)00178-1
          10.1016/j.virusres.2015.05.007
          26003955

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