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      Sedentary behaviour and the risk of depression: a meta-analysis.

      1 , 1 , 1
      British journal of sports medicine
      Epidemiology, Psychology

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          Abstract

          Sedentary behaviour is associated with risk of depression. We review and quantitatively summarise the evidence from observational studies in a meta-analysis.

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          Most cited references21

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          Evidence-based health policy--lessons from the Global Burden of Disease Study.

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            Meta-analysis of genetic association studies.

            Meta-analysis, a statistical tool for combining results across studies, is becoming popular as a method for resolving discrepancies in genetic association studies. Persistent difficulties in obtaining robust, replicable results in genetic association studies are almost certainly because genetic effects are small, requiring studies with many thousands of subjects to be detected. In this article, we describe how meta-analysis works and consider whether it will solve the problem of underpowered studies or whether it is another affliction visited by statisticians on geneticists. We show that meta-analysis has been successful in revealing unexpected sources of heterogeneity, such as publication bias. If heterogeneity is adequately recognized and taken into account, meta-analysis can confirm the involvement of a genetic variant, but it is not a substitute for an adequately powered primary study.
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              Too much sitting: a novel and important predictor of chronic disease risk?

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                Author and article information

                Journal
                Br J Sports Med
                British journal of sports medicine
                1473-0480
                0306-3674
                Jun 2015
                : 49
                : 11
                Affiliations
                [1 ] Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, Shandong, China.
                Article
                bjsports-2014-093613
                10.1136/bjsports-2014-093613
                25183627
                c2d52bf8-61c7-4758-b848-bb0f8443582a
                Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
                History

                Epidemiology,Psychology
                Epidemiology, Psychology

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