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      John Eccles (1903-97) and the experiment that proved chemical synaptic transmission in the central nervous system.

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          Abstract

          One of the most important experiments in neurophysiology in the twentieth century took place in the physiology laboratories at the University of Otago, New Zealand, in August 1951. The group of researchers led by John Eccles convincingly established that synaptic transmission in the central nervous system was a chemical process. This work was the culmination of a long debate between advocates of electrical and chemical transmission. The conclusions overturned Eccles's previous theories of an electrical "Golgi-cell" mechanism and represent a pivotal moment in the history of neuroscience.

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          Author and article information

          Journal
          J Clin Neurosci
          Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
          Elsevier BV
          0967-5868
          0967-5868
          Sep 2008
          : 15
          : 9
          Affiliations
          [1 ] School of Medicine, University of Queensland, Brisbane, Queensland 4000, Australia. drtodman@optusnet.com.au
          Article
          S0967-5868(08)00024-6
          10.1016/j.jocn.2008.01.001
          18617413
          c2de7475-a7a0-4f87-81d9-861b07c1d811
          History

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