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      Focused ultrasound for treatment of bone tumours

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      International Journal of Hyperthermia
      Informa UK Limited

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          The Karnofsky Performance Status Scale. An examination of its reliability and validity in a research setting.

          The Karnofsky Performance Status Scale (KPS) is widely used to quantify the functional status of cancer patients. However, limited data exist documenting its reliability and validity. The KPS is used in the National Hospice Study (NHS) as both a study eligibility criterion and an outcome measure. As part of intensive training, interviewers were instructed in and tested on guidelines for determining the KPS levels of patients. After 4 months of field experience, interviewers were again tested based on narrative patient descriptions. The interrator reliability of 47 NHS interviewers was found to be 0.97. The construct validity of the KPS was analyzed, and the KPS was found to be strongly related (P less than 0.001) to two other independent measures of patient functioning. Finally, the relationship of the KPS to longevity (r = 0.30) in a population of terminal cancer patients documents its predictive validity. These findings suggest the utility of the KPS as a valuable research tool when employed by trained observers.
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            Principles of and advances in percutaneous ablation.

            Image-guided tumor ablation with both thermal and nonthermal sources has received substantial attention for the treatment of many focal malignancies. Increasing interest has been accompanied by continual advances in energy delivery, application technique, and therapeutic combinations with the intent to improve the efficacy and/or specificity of ablative therapies. This review outlines clinical percutaneous tumor ablation technology, detailing the science, devices, techniques, technical obstacles, current trends, and future goals in percutaneous tumor ablation. Methods such as chemical ablation, cryoablation, high-temperature ablation (radiofrequency, microwave, laser, and ultrasound), and irreversible electroporation will be discussed. Advances in technique will also be covered, including combination therapies, tissue property modulation, and the role of computer modeling for treatment optimization. © RSNA, 2011.
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              Society of Interventional Radiology Clinical Practice Guidelines

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                Author and article information

                Journal
                International Journal of Hyperthermia
                International Journal of Hyperthermia
                Informa UK Limited
                0265-6736
                1464-5157
                May 08 2015
                April 03 2015
                March 31 2015
                April 03 2015
                : 31
                : 3
                : 260-271
                Article
                10.3109/02656736.2015.1006690
                c2e55265-9850-4b8f-b6b4-263253c924a9
                © 2015
                History

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