[1
]Singapore Eye Research Institute , Singapore 169856, Singapore
[2
]Duke-NUS Graduate Medical School, National University of Singapore , Singapore 169857, Singapore
[3
]Department of Ophthalmology, National University of Singapore and National University
Health System , Singapore 119228, Singapore
[4
]Singapore National Eye Center , Singapore 168751, Singapore
[5
]Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School
of Medicine , Kyoto 6068507, Japan
[6
]Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong , Hong Kong, China
[7
]Department of Ophthalmology, Seoul Metropolitan Government Seoul National University
Boramae Medical Center , Seoul 156-707, Korea
[8
]Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University
of Electronic Science and Technology of China and Sichuan Provincial People's Hospital , Chengdu 610072, China
[9
]School of Medicine, University of Electronic Science and Technology of China , Chengdu 610072, China
[10
]Key Laboratory of Vision Loss and Restoration, Ministry of Education of China , Beijing 100044, China
[11
]Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases , Beijing 100871, China
[12
]Department of Ophthalmology, People’s Hospital, Peking University , Beijing 100871, China
[13
]Center for Genomic Medicine/Inserm U.852, Kyoto University Graduate School of Medicine , Kyoto 6068507, Japan
[14
]Princess Alexandra Eye Pavilion , Edinburgh EH3 9HA, UK
[15
]National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore 308433, Singapore
[16
]Division of Human Genetics, Genome Institute of Singapore , Singapore 138672, Singapore
[17
]Eye and Retinal Surgeons, Camden Medical Centre , Singapore 248649, Singapore
[18
]Saw Swee Hock School of Public Health, National University of Singapore and National
University Health System , Singapore 117549, Singapore
[19
]Department of Ophthalmology, Saitama Medical University , Iruma 3500495, Japan
[20
]Department of Ophthalmology, Faculty of Medicine, University of Yamanashi , Yamanashi 4093898, Japan
[21
]Department of Ophthalmology, Tokyo Women’s Medical University Hospital , Tokyo 1628666, Japan
[22
]Department of Surgery, Division of Ophthalmology, Kobe University Graduate School
of Medicine , Kobe 6500017, Japan
[23
]Shantou University/Chinese University of Hong Kong Joint Shantou International Eye
Center , Shantou 515041, China
[24
]Zhongshan Ophthalmic Center, Sun Yat-Sen University , Guangzhou 510060, China
[25
]Aier School of Ophthalmology, Central South University , Changsha 410000, China
[26
]Department of Ophthalmology, Xin Hua Hospital affiliated to Shanghai Jiao Tong University,
School of Medicine , Shanghai 200025, China
[27
]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University,
Beijing Institute of Ophthalmology , Beijing 100730, China
[28
]Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute , Pittsburgh, Pennsylvania 15260, USA
[29
]Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, USA
[30
]Hebrew University, School of Public Health , Jerusalem 91120, Israel
[31
]Department of Ophthalmology, Seoul National University Bundang Hospital , Gyeonggi 463-707, Korea
[32
]Department of Ophthalmology, University of Sydney and Westmead Millennium Institute , Sydney 2145, Australia
[33
]Eye and ENT Hospital of Fudan University , Shanghai 200433, China
[34
]BGI-Shenzhen , Shenzhen 518083, China
[35
]Ozaki Eye Hospital , Miyazaki 8830066, Japan
[36
]Mizoguchi Eye Hospital , Nagasaki 8570016, Japan
[37
]Department of Ophthalmology, Kobe City General Hospital , Kobe 6500046, Japan
[38
]Department of Ophthalmology, Seoul National University Hospital, Seoul National University
College of Medicine , Seoul 110-744, Korea
[39
]Department of Ophthalmology, School of Medicine, Kyungpook National University , Daegu 700-721, Korea
[40
]Department of Ophthalmology, Yeungnam University College of Medicine , Daegu 705-802, Korea
[41
]Department of Ophthalmology, College of Medicine, Kosin University , Pusan 606-701, Korea
[42
]Department of Ophthalmology, Pusan Paik Hospital, Inje University College of Medicine , Pusan 614-735, Korea
[43
]Department of Ophthalmology, Pusan National University Hospital , Pusan 602-739, Korea
[44
]Medical Research Institute, Pusan National University , Pusan 602-739, Korea
[45
]Department of Pediatrics, National University Health System and National University
of Singapore , Singapore 119228, Singapore
[46
]Department of Gastroenterology, Asan Medical Center and University of Ulsan College
of Medicine , Seoul 138-736, Korea
[47
]Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine , Seoul 138-736, Korea
[48
]State Key Laboratory of Oncology in Southern China , Guangzhou 510060, China
[49
]Department of Experimental Research, Sun Yat-Sen University Cancer Center , Guangzhou 510080, China
[50
]Peking Union Medical College, Chinese Academy of Medical Science , Beijing 100730, China
[51
]Department of Medicine, National University Health System and National University
of Singapore , Singapore 119228, Singapore
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Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here,
the authors carry out a two-stage genome-wide association study for AMD and identify
three new AMD risk loci, highlighting the shared and distinct genetic basis of the
disease in East Asians and Europeans.
