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      The acute effects of alcohol on auditory thresholds

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          Abstract

          Background

          There is very little knowledge about alcohol-induced hearing loss. Alcohol consumption and tolerance to loud noise is a well observed phenomenon as seen in the Western world where parties get noisier by the hour as the evening matures. This leads to increase in the referrals to the "hearing aid clinic" and the diagnosis of "cocktail party deafness" which may not necessarily be only due to presbyacusis or noise-induced hearing loss.

          Methods

          30 healthy volunteers were recruited for this trial which took place in a controlled acoustic environment. Each of the individuals was required to consume a pre-set amount of alcohol and the hearing was tested (using full pure tone audiogram) pre- and post- alcohol consumption over a broad range of 6 frequencies. Volunteers who achieve a minimum breath alcohol threshold level of 30 u/l had to have second audiogram testing. All the volunteers underwent timed psychometric and visuo-spatial skills tests to detect the effect of alcohol on the decision-making and psychomotor co-ordination.

          Results

          Our results showed that there was a positive association between increasing breath alcohol concentration and the magnitude of the increase in hearing threshold for most hearing frequencies. This was calculated by using the Pearson Regression Coefficient Ratio which was up to 0.6 for hearing at 1000 Hz. Over 90% of subjects had raised auditory thresholds in three or more frequencies; this was more marked in the lower frequencies.

          Conclusion

          Alcohol specifically blunts lower frequencies affecting the mostly 1000 Hz, which is the most crucial frequency for speech discrimination. In conclusion alcohol does appear to affect auditory thresholds with some frequencies being more affected than others.

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          Most cited references11

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          The impact of alcohol, tobacco, and other drug use and abuse in the emergency department.

          Alcohol, tobacco, and other drug use is a significant societal problem. Individuals who use these substances are frequently seen in emergency departments at rates disproportionately greater than their population prevalence. This article highlights the impact of these drugs on patients and on emergency departments, including common presenting problems of individuals on these substances. Also discussed is how to help and to refer individuals with substance abuse problems through brief motivational interventions.
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            Alcohol impairs auditory processing of frequency changes and novel sounds: a combined MEG and EEG study.

            Alcohol has been shown to impair involuntary attention studied by event-related potentials using mismatch negativity (MMN) and P3a. However, no studies have investigated whether alcohol affects the magnetic counterparts of N1 (N1m), MMN (MMNm) and P3a (P3am). Auditory evoked potentials and magnetic fields elicited by infrequent deviant tones differing in frequency (5% and 20% change) and novel sounds were recorded with whole-head magnetoencephalography (MEG) and electroencephalography (EEG). Stimuli were presented separately to the left and right ear. Eleven right-handed subjects were studied in a double-blind, placebo-controlled (0.8 g/kg ethanol or juice), cross-over design. N1m, MMNm, and P3am were calculated from the channel pair at the temporal cortex showing the strongest responses in the hemisphere contralateral to the stimulation. N1, MMN and P3a were analyzed from 12 electrodes at the midline frontocentral area. Alcohol reduced bilaterally N1, N1m, MMN and MMNm amplitudes. P3a amplitudes, but not P3am amplitudes were also significantly decreased. No effects of alcohol on the latencies of N1, MMN and P3a or their magnetic counterparts were observed. Alcohol impairs the processing of tones, frequency change and novel sounds at different phases of auditory processing similarly in both hemispheres. MEG provides us with additional information unobtainable with EEG about the effects of alcohol on the neural correlates of cognition.
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              Acute effects of alcohol on auditory thresholds and distortion product otoacoustic emissions in humans.

              To investigate the acute effects of alcohol consumption on pure-tone thresholds (PTs) and distortion product otoacoustic emissions (DPOAEs) in humans Eight healthy adults were asked to drink alcohol to the clinical intoxication level. PTs and DPOAEs were determined serially before and after alcohol ingestion. Alcohol had no effect on PTs DPOAE amplitudes above 5500 Hz dropped 30 min and 1 h after alcohol ingestion, returning to the pre-test level 2 h after ingestion. In humans, acute alcohol consumption to the intoxication level may cause a temporary reduction in DPOAE amplitudes at high frequencies without affecting auditory thresholds.
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                Author and article information

                Journal
                BMC Ear Nose Throat Disord
                BMC Ear, Nose, and Throat Disorders
                BioMed Central (London )
                1472-6815
                2007
                18 September 2007
                : 7
                : 4
                Affiliations
                [1 ]Head & Neck Unit, University College London Hospitals, London, UK
                [2 ]Royal National Throat, Nose and Ear Hospital, London, UK
                Article
                1472-6815-7-4
                10.1186/1472-6815-7-4
                2031886
                17877829
                c307030a-dbb7-4ed1-9b4a-e0b11f0daab5
                Copyright © 2007 Upile et al; licensee BioMed Central Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 6 December 2006
                : 18 September 2007
                Categories
                Research Article

                Otolaryngology
                Otolaryngology

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