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      Desórdenes hipertensivos asociados a desprendimiento prematuro grave de placenta normoinserta Translated title: Hypertensive disorders associated with severe abruption placentae

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          Abstract

          Para evaluar el desarrollo de la vellosidad de anclaje, en desórdenes hipertensivos del embarazo, asociados con desprendimiento prematuro grave de placenta normoinserta (DPGPN), en el laboratorio de microscopía electrónica de la Facultad de Ciencias de la Salud. Universidad de Carabobo se examinaron 20 placentas, 17 con desórdenes hipertensivos y tres de embarazos normales, en el tercer trimestre, aplicándose protocolo con las variables que determinan tipos de vellosidades según su desarrollo y cambios degenerativos encontrados con microscopía de luz. Se encontró 91% de vellosidad troncal, 92% de intermedia madura, 28% de intermedia inmadura, 47% de terminales, 92% con membrana vásculosincitial periférica y 44% de membrana vásculosincitial central y notables cambios degenerativos como cambios fibrinoides en el 100%, igual la necrosis del trofoblasto, 96% de fibrosis estromal, 88% de edema y 74% de hemorragia; además 92% de trombosis, congestión vascular y cambios de la pared del vaso y más de seis vasos en las vellosidades en 52%. El espacio íntervelloso tiene importantes cambios como los depósitos de fibrina en 84%, la trombosis íntervellosa en 76% y los infartos en 56%, estos cambios degenerativos son estadísticamente significativos. Conclusión: un acelerado crecimiento de la vellosidad empotrada en la placa basal o cercana a ella se evidencia en los resultados con simultáneos procesos indicativos de degeneración y desarrollo anormal en un ambiente de daño velloso hipóxico extenso.

          Translated abstract

          To evaluate the development of placental anchoring villi of the basal plate in hypertensive disorders of pregnancy associated with abruption placentae severe. Twenty placentas were examined. Seventeen patients with hypertensive disorders and three of normal pregnancy during the third trimester of gestation applying a protocol in order to determine types of villi according to their development and degenerative changes found with light microscopy. We found 91% of stem villi, 92% of intermediate mature villi, 28% of intermediate immature villi, 47% of terminal villi, 92% with peripheral and 44% vascular sincitial membrane and 44% central vascular sincitial membrane also remarkable degenerative changes, as fibrinoide deposits and trophoblastic necrosis in 100%, fibrous stroma 96%, edema 88% and hemorrhage 74%; moreover 92% off thrombosis, vascular congestion and changes vessel wall and mayor six vessel in 52%. Intervellous space have important changes as fibrin deposits in 84%, intervellous thrombosis 76% and intervellous attach 56%. All degenerative changes are statistically significant. Conclusion: An accelerated development of placental anchor villi or of other villous types near to basal plate were seen with simultaneous processes indicative of degeneration as extensive hypoxic villous damage and abnormal development.

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          Most cited references17

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          Metodología de la investigación

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            Histología sobre bases biomoleculares

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              Abruptio placentae; dangers of delay in delivery.

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                Author and article information

                Journal
                s
                Salus
                Salus
                Universidad de Carabobo (Valencia, Carabobo, Venezuela )
                1316-7138
                August 2012
                : 16
                : 2
                : 9-14
                Affiliations
                [02] orgnameUniversidad de Carabobo orgdiv1Centro de Investigación y Análisis Docente Asistencial
                [01] Maracay Aragua orgnameMaternidad La Floresta C.A
                Article
                S1316-71382012000200003 S1316-7138(12)01600203
                c30add91-bcc5-44b8-81df-99693a942d8e

                http://creativecommons.org/licenses/by/4.0/

                History
                : September 2011
                : January 2012
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 15, Pages: 6
                Product

                SciELO Venezuela

                Categories
                Artículos

                placental development,desorden hipertensivo,desprendimiento,vellosidad placentaria,desarrollo placentario,hypertensive disorder,abruption placentae,placental villi

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