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      Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

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          Abstract

          Effective intraocular drug delivery poses a major challenge due to the presence of various elimination mechanisms and physiological barriers that result in low ocular bioavailability after topical application. Over the past decades, polymeric micelles have emerged as one of the most promising drug delivery platforms for the management of ocular diseases affecting the anterior (dry eye syndrome) and posterior (age-related macular degeneration, diabetic retinopathy and glaucoma) segments of the eye. Promising preclinical efficacy results from both in-vitro and in-vivo animal studies have led to their steady progression through clinical trials. The mucoadhesive nature of these polymeric micelles results in enhanced contact with the ocular surface while their small size allows better tissue penetration. Most importantly, being highly water soluble, these polymeric micelles generate clear aqueous solutions which allows easy application in the form of eye drops without any vision interference. Enhanced stability, larger cargo capacity, non-toxicity, ease of surface modification and controlled drug release are additional advantages with polymeric micelles. Finally, simple and cost effective fabrication techniques render their industrial acceptance relatively high. This review summarizes structural frameworks, methods of preparation, physicochemical properties, patented inventions and recent advances of these micelles as effective carriers for ocular drug delivery highlighting their performance in preclinical studies.

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          Author and article information

          Journal
          8607908
          21032
          J Control Release
          J Control Release
          Journal of controlled release : official journal of the Controlled Release Society
          0168-3659
          1873-4995
          25 January 2017
          11 January 2017
          28 February 2017
          28 February 2018
          : 248
          : 96-116
          Affiliations
          [a ]Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA
          [b ]Buchanan Ocular Therapeutics Unit (BOTU), Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand
          Author notes
          [* ] Corresponding author: Ashim K. Mitra, PhD, Curators Distinguished Professor of Pharmacy, Chair, Division of Pharmaceutical Sciences, Vice-Provost for Interdisciplinary Research, University of Missouri-Kansas City, Phone: 816-235-1615, Fax: 816-235-5190, mitraa@ 123456umkc.edu
          Article
          PMC5319397 PMC5319397 5319397 nihpa844951
          10.1016/j.jconrel.2017.01.012
          5319397
          28087407
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