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      Additive effect of anti-citrullinated protein antibodies and rheumatoid factor on bone erosions in patients with RA.

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          Abstract

          To determine whether there is an additive effect of anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) on the number and size of bone erosions in patients with rheumatoid arthritis (RA) METHODS: 242 patients with RA received high-resolution peripheral quantitative CT (HR-pQCT) scans of the metacarpophalangeal joints. Demographic and disease-specific parameters including ACPA and RF levels were recorded from all patients. Erosion numbers and their size were assessed in 238 patients at 714 individual joints (MCP 2, 3 and 4) and 5712 sites (each 4 quadrants in metacarpal heads and phalangeal bases). The volume of erosions was calculated by a semiellipsoid formula.

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          Author and article information

          Journal
          Ann. Rheum. Dis.
          Annals of the rheumatic diseases
          1468-2060
          0003-4967
          Dec 2015
          : 74
          : 12
          Affiliations
          [1 ] Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.
          [2 ] Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany.
          Article
          annrheumdis-2014-205428
          10.1136/annrheumdis-2014-205428
          25115448
          c3145ad8-9b91-4472-9094-f39824e54735
          Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
          History

          Ant-CCP,Rheumatoid Arthritis,Rheumatoid Factor
          Ant-CCP, Rheumatoid Arthritis, Rheumatoid Factor

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