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HIV infection-related tuberculosis: clinical manifestations and treatment.

Author(s): R Chaisson, Quynh Pham, Timothy Sterling

Publication date: 2010-05-15

Journal: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

Keywords: pathology, drug therapy, Tuberculosis, Immune Reconstitution Inflammatory Syndrome, Humans, complications, HIV Infections, Drug Interactions, therapeutic use, Antitubercular Agents, Anti-HIV Agents, AIDS-Related Opportunistic Infections

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Abstract

Several aspects of human immunodeficiency virus (HIV) infection-related tuberculosis (TB) and its treatment differ from those of TB in HIV-uninfected persons. The risk of TB and the clinical and radiographic manifestations of disease are primary examples. Antiretroviral therapy has a profound effect on lowering the risk of TB in HIV-infected persons, but it can also be associated with immune reconstitution inflammatory disease and unmasking of previously subclinical disease. There are also differences in treatment of HIV infection-related TB because of overlapping drug toxicities and drug-drug interactions between antiretroviral therapy and anti-TB therapy.

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DOI:: 10.1086/651495

PubMed ID:: 20397952

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ScienceOpen disciplines: Chemistry

HIV infection-related tuberculosis: clinical manifestations and treatment.

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