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      p16/Ki-67 Immunocytochemistry in Gynecological Cytology: Limitations in Practice.

      1

      Acta cytologica

      S. Karger AG

      Biomarker, CIN, Cervical cytology, Ki-67, Methodical limitations, p16

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          Abstract

          Immunochemical detection of the protein p16INK4a in cervical cytology is used in combination with Ki-67. Cells positive for both proteins are certain to have been transformed by high-risk HPV. p16/Ki-67 immunocytochemistry provides a significant improvement in specificity over cytology and HPV DNA testing. However, p16/Ki-67 immunocytochemistry also has its limitations.

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          Author and article information

          Journal
          Acta Cytol.
          Acta cytologica
          S. Karger AG
          1938-2650
          0001-5547
          May 19 2017
          Affiliations
          [1 ] Institute of Pathology, Potsdam-Bornstedt, Germany.
          000475979
          10.1159/000475979
          28521315

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