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      Prediction of Advanced Puberty by Height Velocity in Children with Acute Lymphoblastic Leukemia

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          Abstract

          Pubertal development was retrospectively evaluated in 58 children with cancer, mostly acute lymphoblastic leukemia (ALL), who are in complete remission and off chemotherapy. Six girls [5 patients with ALL, and 1 with malignant lymphoma (NHL)] showed advanced puberty (25.0%, 6 of 24 female patients with ALL and NHL) through the evaluation of their growth velocity. No evidence for advanced puberty was seen in the males. All 6 girls had received cranial irradiation for central nervous system prophylaxis and systemic chemotherapy including glucocorticoid. The mean age at onset of the pubertal growth spurt in these 6 girls was significantly lower than for girls with a solid tumor [6.90 ± 0.10 and 9.00 ± 0.77 (mean ± SD) years, respectively (p < 0.001)]. By simply evaluating the height velocity, we could predict advanced puberty which was ultimately associated with short stature.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1992
          1992
          03 December 2008
          : 37
          : 3
          : 81-85
          Affiliations
          aDepartment of Pediatrics, and bTumor Clinical Research Center, Mie University School of Medicine, Japan
          Article
          182287 Horm Res 1992;37:81–85
          10.1159/000182287
          1478627
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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