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      Preliminary Evidence for a Human Prolactin Releasing Factor

      , ,

      Neuroendocrinology

      S. Karger AG

      TRF, PIF, PRF

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          Abstract

          Plasma from normal human subjects was subjected to a 3-phase methanol extraction. An increase in prolactin release from rat anterior pituitary tissue in vitro obtained with increasing doses of the plasma extract, while no increase in TSH release occurred. Control studies with an extract of simulated plasma using incubation medium with human serum albumin resulted in less release than a comparable plasma extract dose. The plasma extract did not lose activity with heating to 100°C for 10 min, and incubation of normal plasma at 37 °C for 4 h prior to methanol extraction resulted in no loss of prolactin releasing activity. The plasma extract was subjected to cascade ultra-filtration through UM-10, UM-2, and UM-0.5 filters with no significant loss of prolactin releasing activity. Finally, the extract contained no TRH immunoreactivity. These results support the existence of a heat stable, ultra-filterable circulating PRF in human plasma. The origin of this material is unknown.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1976
          1976
          25 March 2008
          : 21
          : 3
          : 255-261
          Affiliations
          Department of Medicine, The Medical College of Wisconsin and The Veterans Administration Center, Milwaukee, Wisc.
          Article
          122530 Neuroendocrinology 1976;21:255–261
          10.1159/000122530
          828244
          © 1976 S. Karger AG, Basel

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          Pages: 7
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