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      An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites

      1 , 2 , 3 , 1 , 1 , 4 , 1
      Journal of Pharmacy and Pharmacology
      Wiley

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          Tumor delivery of macromolecular drugs based on the EPR effect.

          Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors. Copyright © 2010 Elsevier B.V. All rights reserved.
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            Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals.

            Mesoporous silica nanoparticles (MSNs) are a promising material for drug delivery. In this Full Paper, MSNs are first shown to be well tolerated, as demonstrated by serological, hematological, and histopathological examinations of blood samples and mouse tissues after MSN injection. Biodistribution studies using human cancer xenografts are carried out with in vivo imaging and fluorescent microscopy imaging, as well as with inductively coupled plasma mass spectroscopy. The results show that MSNs preferentially accumulate in tumors. Finally, the drug-delivery capability of MSNs is demonstrated by following tumor growth in mice treated with camptothecin-loaded MSNs. These results indicate that MSNs are biocompatible, preferentially accumulate in tumors, and effectively deliver drugs to the tumors and suppress tumor growth.
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              The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting

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                Author and article information

                Contributors
                (View ORCID Profile)
                (View ORCID Profile)
                Journal
                Journal of Pharmacy and Pharmacology
                J Pharm Pharmacol
                Wiley
                0022-3573
                2042-7158
                May 24 2019
                August 2019
                May 03 2019
                August 2019
                : 71
                : 8
                : 1185-1198
                Affiliations
                [1 ]CNRS, CAMB, UMR 7199 Université de Strasbourg Strasbourg France
                [2 ]Department of Bioengineering Clemson University Clemson SC USA
                [3 ]National Research Centre Cairo Egypt
                [4 ]Department of Pharmaceutical Chemistry Faculty of Pharmacy Umm Al‐Qura University Umm Al‐Qura Kingdom of Saudi Arabia
                Article
                10.1111/jphp.13098
                31049986
                c35158ad-bd40-4035-8e32-7c5bf71f9764
                © 2019

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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