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      Evolution of Our Understanding of the Hyperparathyroid Syndromes: A Historical Perspective

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          Abstract

          We review advancing and overlapping stages for our understanding of 6 hyperparathyroid (HPT) syndromes: multiple endocrine neoplasia type 1 (MEN1) or type 4, multiple endocrine neoplasia type 2A (MEN2A), hyperparathyroidism-jaw tumor syndrome, familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and familial isolated hyperparathyroidism. During stage 1 (1903-1967), the introduction of serum calcium measurement was a milestone that uncovered hypercalcemia as the first sign of dysfunction in many HPT subjects. Inheritability was reported in each syndrome. The earliest reports of HPT syndromes were biased towards severe or striking manifestations. During stage 2 (1959-1985), syndromes were more fully formulated. Radioimmunoassays (PTH, gastrin, insulin, prolactin, calcitonin) were breakthroughs. They could identify a syndrome carrier, indicate an emerging tumor, characterize a tumor, or monitor a tumor. During stage 3 (1981-2006), the assembly of many cases enabled recognition of further details. Age-related penetrance of a syndrome could be derived. Hormone non-secreting skin lesions were discovered in MEN1 and MEN2A. Genetic linkage could now be used for carrier detection. During stage 4 (1985 to the present), new genomic tools were a revolution for gene identification. Four principal genes (“principal” implies mutated or deleted in 50% or more probands for its syndrome) ( MEN1, RET, CASR, CDC73) were identified for 5 syndromes. During stage 5 (1993 to the present), 7 syndromal genes other than a principal gene were identified ( CDKN1B, CDKN2B, CDKN2C, CDKN1A, GNA11, AP2S1, GCM2). Identification of AP2S1 and GCM2 became possible because of whole exome sequencing. During stages 4 and 5, the identified genes enabled many studies, including robust detection of mutation carriers and non-carriers. Furthermore, molecular pathways of RET and the calcium-sensing receptor were elaborated, thereby facilitating developments in pharmacotherapy. Current findings hold the promise that more genes for HPT syndromes will be identified and studied in the near future.

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          Author and article information

          Journal
          8610640
          104
          J Bone Miner Res
          J. Bone Miner. Res.
          Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
          0884-0431
          1523-4681
          11 January 2019
          10 December 2018
          January 2019
          01 March 2019
          : 34
          : 1
          : 22-37
          Affiliations
          [1. ]Office of the Scientific Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda Maryland
          [2. ]Calcium Research Laboratory, Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, 1001 Decarie Blvd, Room EM1.3220, Montreal, Quebec, Canada H4A 3J1
          Author notes
          Corresponding author: Dr. Stephen Marx, 301-525-1817, stephen1.marx1@ 123456gmail.com , Bld 6A, Room 1A-08A, MSC 0614, 6 Center Drive, N.I.H., Bethesda, MD, 20892

          Authors’ roles

          Study design: SM and DG. Data collection: SM and DG. Data interpretation: SM and DG. First draft of manuscript: SM. Revising manuscript content: SM and DG. Approving final version of manuscript: SM and DG. SM and DG take responsibility for the integrity of the data collection and interpretation.

          Article
          PMC6396287 PMC6396287 6396287 nihpa1517527
          10.1002/jbmr.3650
          6396287
          30536424
          Categories
          Article

          GNA11, CDKN1B, CASR, CDC73, RET, MEN1, GCM2, AP2S1

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