Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine

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Abstract

Cell dedifferentiation is the process by which cells grow reversely from a partially or terminally differentiated stage to a less differentiated stage within their own lineage. This extraordinary phenomenon, observed in many physiological processes, inspires the possibility of developing new therapeutic approaches to regenerate damaged tissue and organs. Meanwhile, studies also indicate that dedifferentiation can cause pathological changes. In this review, we compile the literature describing recent advances in research on dedifferentiation, with an emphasis on tissue-specific findings, cellular mechanisms, and potential therapeutic applications from an engineering perspective. A critical understanding of such knowledge may provide fresh insights for designing new therapeutic strategies for regenerative medicine based on the principle of cell dedifferentiation.

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Most cited references 110

Record: found
Abstract: found
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The origin and development of glial cells in peripheral nerves.

Kristjan Jessen, Rhona Mirsky (2005)

During the development of peripheral nerves, neural crest cells generate myelinating and non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of the CNS. Unlike central gliogenesis, neural crest development involves a protracted embryonic phase devoted to the generation of, first, the Schwann cell precursor and then the immature Schwann cell, a cell whose fate as a myelinating or non-myelinating cell has yet to be determined. Embryonic nerves therefore offer a particular opportunity to analyse the early steps of gliogenesis from transient multipotent stem cells, and to understand how this process is integrated with organogenesis of peripheral nerves.

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Record: found
Abstract: found
Article: not found

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.

Enzo Porrello, Ahmed Mahmoud, Emma Simpson … (2013)

We recently identified a brief time period during postnatal development when the mammalian heart retains significant regenerative potential after amputation of the ventricular apex. However, one major unresolved question is whether the neonatal mouse heart can also regenerate in response to myocardial ischemia, the most common antecedent of heart failure in humans. Here, we induced ischemic myocardial infarction (MI) in 1-d-old mice and found that this results in extensive myocardial necrosis and systolic dysfunction. Remarkably, the neonatal heart mounted a robust regenerative response, through proliferation of preexisting cardiomyocytes, resulting in full functional recovery within 21 d. Moreover, we show that the miR-15 family of microRNAs modulates neonatal heart regeneration through inhibition of postnatal cardiomyocyte proliferation. Finally, we demonstrate that inhibition of the miR-15 family from an early postnatal age until adulthood increases myocyte proliferation in the adult heart and improves left ventricular systolic function after adult MI. We conclude that the neonatal mammalian heart can regenerate after myocardial infarction through proliferation of preexisting cardiomyocytes and that the miR-15 family contributes to postnatal loss of cardiac regenerative capacity.

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Record: found
Abstract: found
Article: not found

A decade of progress in tissue engineering.

Ali Khademhosseini, Robert Langer (2016)

Tremendous progress has been achieved in the field of tissue engineering in the past decade. Several major challenges laid down 10 years ago, have been studied, including renewable cell sources, biomaterials with tunable properties, mitigation of host responses, and vascularization. Here we review advancements in these areas and envision directions of further development.

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Author and article information

Contributors

Chunming Wang:

ORCID: http://orcid.org/0000-0001-9185-9678

CMWang@umac.mo

Journal

Journal ID (nlm-ta): NPJ Regen Med

Journal ID (iso-abbrev): NPJ Regen Med

Title: NPJ Regenerative Medicine

Publisher: Nature Publishing Group UK (London )

ISSN (Electronic): 2057-3995

Publication date (Electronic): 31 July 2020

Publication date PMC-release: 31 July 2020

Publication date Collection: 2020

Volume: 5

Electronic Location Identifier: 14

Affiliations

[1 ]GRID grid.470124.4, Department of Joint Surgery, , The First Affiliated Hospital of Guangzhou Medical University, ; 510120 Guangzhou, China

[2 ]Guangdong Key Laboratory of Orthopaedic Technology and Implant Materials, Guangzhou, China

[3 ]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China

Author information

Yongchang Yao http://orcid.org/0000-0002-4338-2606

Chunming Wang http://orcid.org/0000-0001-9185-9678

Article

Publisher ID: 99

DOI: 10.1038/s41536-020-00099-8

PMC ID: 7395755

PubMed ID: 32821434

SO-VID: c39bc8f5-54e9-4008-9e26-c3936e35839a

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 8 November 2019

Date accepted : 8 July 2020

Funding

Funded by: Fundo para o Desenvolvimento das Ciências e da Tecnologia (Grant No. FDCT 080/2016/A2 and 126/2016/A3) University of Macau (Grant No. MYRG2017‐00028‐ICMS)

Funded by: Science and Technology Program of Guangzhou, China (grant number 201804010479) Key Programme for Scientific Research Project of Guangzhou Colleges and Universities (grant number 1201610097)