Immunogenicity and Safety of Yellow Fever Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients After Withdrawal of Immunosuppressive Therapy.

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Abstract

As a live attenuated vaccine, yellow fever vaccine (YFV) is not routinely performed after allogeneic hematopoietic stem cell transplant (HSCT) despite it being the only efficient preventive therapy. We retrospectively identified 21 HSCT recipients immunized with YFV at a median of 39 months after HSCT and a median of 33 months after withdrawal of immunosuppression without any side effects. Eighteen evaluable patients had protective immunity after YFV. We also observed that a third of the recipients vaccinated with YFV before HSCT had persistent protective immunity after HSCT.

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Journal

Journal ID (iso-abbrev): J Infect Dis

Title: The Journal of infectious diseases

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1537-6613

ISSN (Print): 0022-1899

Publication date (Electronic): January 17 2018

Volume: 217

Issue: 3

Affiliations

[1 ] Service d'Hématologie Greffe, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP).

[2 ] Service de Pédiatrie, Centre Hospitalier Intercommunal de Créteil.

[3 ] Service d'Hématologie Clinique, Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Hôpital Necker-Enfants Malades, AP-HP.

[4 ] INSERM U941, Service de Microbiologie, Hôpital Saint-Louis, AP-HP, Paris.

[5 ] Service d'Hématologie Clinique, Hôpital d'Instruction des Armées, Clamart.

[6 ] Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, Université Pierre et Marie Curie, Paris.

[7 ] Service d'Hématologie, Hôpital Henri Mondor, AP-HP, Université Paris Est, Créteil.

[8 ] Service de Maladies Infectieuses, Hôpital Saint-Louis, AP-HP.

[9 ] Institut Pasteur, Centre Médical, Centre d'Infectiologie Necker-Pasteur, Paris, France.

Article

Publisher Item ID: 4566036

DOI: 10.1093/infdis/jix564

PubMed ID: 29087520

SO-VID: c3b17ff5-d06c-4f35-96c3-b69cbbcbd041

History

Keywords: allogeneic transplantation,immunocompromised,live attenuated vaccine,yellow fever

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Keywords: allogeneic transplantation, immunocompromised, live attenuated vaccine, yellow fever

Immunogenicity and Safety of Yellow Fever Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients After Withdrawal of Immunosuppressive Therapy.

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