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      Sarcomas de partes blandas en pacientes pediátricos: análisis de una serie de casos del subtipo no rabdomiosarcoma Translated title: Pediatric soft tissue sarcomas: analysis of non rhabdomyosarcoma group

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          Abstract

          Se evaluó una serie de 29 pacientes con diagnóstico de sarcomas de partes blandas variante no rabdomiosarcomas tratados quirúrgicamente entre2000 y 2010, y se analizó la supervivencia global y los factores que influyen en el pronóstico. La edad media fue de 11,6 años (rango de 3 meses-17 años); 16 pacientes eran de sexo masculino y el tiempo promedio de seguimiento fue de 56 meses (de 8 a 132 meses). Se documentaron 8 variedades histológicas diferentes de tumores malignos, y el sarcoma sinovial resultó ser el más frecuente (14 pacientes). La cirugía de conservación de miembro fue posible en 28 pacientes y se asoció tratamiento adyuvante en 26. La supervivencia global de la serie estudiada fue de 72% a los 5 años y, en 9 pacientes, se diagnosticó una recurrencia local. La presencia de metástasis (p < 0,0001) y la recurrencia local (p < 0,007) resultaron ser factores de pronóstico negativo para la supervivencia global.

          Translated abstract

          We evaluated 29 patients with non rhabdomyosarcoma soft tissue sarcomas treated with surgery between 2000 and 2010; we analyzed overall survival and which factors affect the prognosis. The mean age was 11.6 years (range 3 months-17 years); 16 patients were males and the median follow-up was 56 months (8 to 132 months). Eight different histological malignant tumors were identified, being synovial sarcoma the most prevalent one (14 patients). Twenty-eight patients were treated with limb salvage surgery and in 26 cases, adjuvant therapy was used. Five years overall survival was 72%. Nine of the 29 patients presented a local recurrence. The presence of metastases (p <0.0001) and local recurrence (p <0.007) were negative prognostic factors for overall survival.

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          Most cited references13

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          Rebuttal from Authors re Axel Heidenreich Identification of High-Risk Prostate Cancer Role of Prostate-Specific Antigen PSA Doubling Time and PSA Velocity Eur Urol 2008 54 976-7

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            Factors predicting local recurrence, metastasis, and survival in pediatric soft tissue sarcoma in extremities

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              Treatment of unresectable or metastatic pediatric soft tissue sarcomas with surgery, irradiation, and chemotherapy: a Pediatric Oncology Group study

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                aap
                Archivos argentinos de pediatría
                Arch. argent. pediatr.
                Sociedad Argentina de Pediatría (Buenos Aires )
                1668-3501
                December 2014
                : 112
                : 6
                : e257-e261
                Affiliations
                [1 ] Hospital Italiano
                Article
                S0325-00752014000600016
                10.5546/aap.2014.e257
                c3b9b212-e324-4fb9-9495-a614f7dd2951

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Argentina

                Self URI (journal page): http://www.scielo.org.ar/scielo.php?script=sci_serial&pid=0325-0075&lng=en
                Categories
                PEDIATRICS

                Pediatrics
                Non rhabdomyosarcoma soft tissue sarcomas,Overall survival,Local recurrence,Sarcomas de partes blandas no rabdomiosarcomas,Supervivencia,Recurrencia local

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