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      Application of gold nanoparticles to microencapsulation of thioridazine.

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          Abstract

          Thioridazine-containing ethyl cellulose (EC) microcapsules were prepared in the presence of gold nanoparticles via the W/O/W emulsification solvent-evaporation method. The gold nanoparticles have been verified as human safe and the nondestructive physisorption of thioridazine on gold nanoparticles was corroborated with the time-of-flight second ion mass spectrometry measurements. The morphology of the formed microcapsules (ETA, containing EC, Thioridazine and Au) changed substantially because of the presence of gold nanoparticles. In addition to a prolonged controlled release, these ETA microcapsules had an enhanced thioridazine encapsulation with an efficiency over one and half times that of the microcapsules (ET) containing no nanogold particles. While data of the release kinetics for ET microcapsules fitted the apparent first-order model, corresponding data for ETA microcapsules agreed better with the Higuchi model indicating a uniform distribution of thioridazine in the monolithic-type microcapsules.

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          Author and article information

          Journal
          J Control Release
          Journal of controlled release : official journal of the Controlled Release Society
          Elsevier BV
          0168-3659
          0168-3659
          Apr 10 2006
          : 111
          : 3
          Affiliations
          [1 ] Department of Chemical Engineering, National Chung Cheng University, Chiayi 621, Taiwan, ROC.
          Article
          S0168-3659(06)00005-8
          10.1016/j.jconrel.2005.12.017
          16478639
          c3bb0ced-1993-4760-a6e8-6dc861d5d096
          History

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