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      Inhibition of Experimental Intraocular Proliferation with Intravitreous 5-Fluouracil

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          Abstract

          5-Fluouracil, administered at concentrations of 1 and 5 mg to inhibit experimental intraocular proliferation produced by intravitreously implanted fibroblasts in rabbits, produced tissue alterations revealed by TEM. The degranulation and migration of pigment epithelial cells, the incipient degradation of axons and myelin sheets, the migration of glial cells and the prominent edema of the inner layers indicated a non-negligible damage to the retina, suggesting to abstain from its use in human eyes and to search for less neurotoxic drugs, possessing the same inhibitory effect on intraocular proliferation.

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          Author and article information

          Journal
          OPH
          Ophthalmologica
          10.1159/issn.0030-3755
          Ophthalmologica
          S. Karger AG
          0030-3755
          1423-0267
          1984
          1984
          31 March 2010
          : 188
          : 4
          : 248-258
          Affiliations
          1st University Eye-Clinic (Head: Prof. H. Freyler) and Institute of Micromorphology and Electron Microscopy (Head: Prof. L. Stockinger), Vienna, Austria
          Article
          309371 Ophthalmologica 1984;188:248–258
          10.1159/000309371
          6739043
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Original Paper

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