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      Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules.

      Natural Product Reports

      Molecular Structure, Glycosylation, Drug Discovery, pharmacokinetics, chemistry, Carbohydrates, pharmacology, metabolism, Biological Products

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          Abstract

          Glyco (randomization/diversification) is a term that encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to provide sets of analogs wherein the sole diversity element is a carbohydrate. This review covers the influence of glycosylation upon various drug properties, the classes of glycosyl-conjugating enzymes amenable to glyco(randomization/diversification) schemes, approaches to the synthesis of required substrates and specific examples of glycorandomized libraries utilizing both wild-type and engineered enzymes.

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          Journal
          10.1039/c1np00045d
          21901218

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