The use of the prone position for surgery presents potential obstacles to rapid tracking of patients during ambulatory anesthesia. We describe a prospective audit of 73 patients who placed themselves in the prone position; anesthesia was induced in this position and a laryngeal mask airway (LMA) was used to maintain the airway. Additional increments of propofol were given to one patient who had laryngospasm and to nine who required deepening of anesthesia before the LMA could be inserted. Of four cases with LMA malpositioning, the LMA was adjusted easily in three, but in one patient who was edentulous, it was necessary to hold the LMA for the duration of the procedure. Manual ventilation of the lungs via the LMA was required because of arterial oxygen desaturation and hypoventilation in four patients. Blood was noted outside the nostrils in two patients, presumably caused by soft tissue trauma after insertion of the LMA, and bradycardia occurred in five patients. In the postoperative period, hoarseness and sore throat were observed in one and six patients, respectively. With experience and appropriate patient selection, it is possible to induce and maintain anesthesia using a LMA in patients in the prone position for ambulatory surgery. With experience and appropriate patient selection, it is possible to induce and maintain anesthesia using a laryngeal mask airway in patients in the prone position for ambulatory surgery.