More than 10 years experience in implementing the Tanaka Johnston and Moyers methods has shown that they overestimate the sizes of unerupted canines and premolars when used in populations other than the Caucasian. This study was designed to assess the applicability of the two most commonly used methods of mixed dentition analysis and to attempt to derive a more accurate and precise formula to predict the sizes of the unerupted premolars and canines in a sample of Indian population.