Cancer caregiving has an impact on the quality of life (QOL) of the caregivers. This cross-sectional study determined the health-related QOL (HRQOL) of gastrointestinal cancer caregivers and associated factors across gender. A total of 323 respondents from major hospitals in Klang Valley completed HRQOL questionnaire from October 2017 to April 2018. Males had a better quality of life compared to females, mean HRQOL score 85.52 (SD=21.16) vs 77.66 (SD=21.36). The significant factors were: relationship between the caregiver and the patient; education level; employment status, marital status, household income and presence of disease. The gender role is vital for targeted intervention.