Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants.

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Abstract

Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin is associated with increased risk of upper gastrointestinal bleeding. There is little evidence on the risk of lower gastrointestinal bleeding with NSAIDs, antiplatelet agents (APAs), or anticoagulants. We aimed to quantify the relative risk (RR) of upper and lower gastrointestinal bleeding associated with use of NSAIDs, APAs, or anticoagulants.

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Journal ID (iso-abbrev): Clin. Gastroenterol. Hepatol.

Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

ISSN (Electronic): 1542-7714

ISSN (Print): 1542-3565

Publication date (Electronic): May 2015

Volume: 13

Issue: 5

Affiliations

[1 ] Servicio de Aparato Digestivo, Hospital Clínico, University of Zaragoza, Zaragoza, Spain; CIBERehd, Barcelona, Spain. Electronic address: alanas@unizar.es.

[2 ] CIBERehd, Barcelona, Spain.

[3 ] Servicio de Aparato Digestivo, Hospital Clínico, University of Zaragoza, Zaragoza, Spain.

[4 ] Servicio de Aparato Digestivo, Hospital Universiatrio Miguel Servet, Zaragoza, Spain.

[5 ] CIBERehd, Barcelona, Spain; Hospital Donostia, San Sebastian, Spain.

[6 ] CIBERehd, Barcelona, Spain; Servicio de Aparato Digestivo, Corporació Sanitària Universitària, Sabadell, Barcelona, Spain.

[7 ] CIBERehd, Barcelona, Spain; Servicio de Aparato Digestivo, Hospital La Fe, Valencia, Spain.

[8 ] Servicio de Aparato Digestivo, Hospital Costa del Sol, Marbella, Spain.

[9 ] CIBERehd, Barcelona, Spain; Gastroenterología, Hospital de Valme, Sevilla, Spain.

[10 ] Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain.

Article

Publisher Item ID: S1542-3565(14)01620-6

DOI: 10.1016/j.cgh.2014.11.007

PubMed ID: 25460554

SO-VID: c402a890-93ed-4e19-828f-6c84481b492e

History

Keywords: Colon,Complication,Intestine,Peptic Ulcer,Side Effect,Small Bowel,Stomach

Data availability:

Keywords: Colon, Complication, Intestine, Peptic Ulcer, Side Effect, Small Bowel, Stomach

Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants.

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