Binding of Monoclonal Antibodies to Platelet Glycoproteins lb and llb/llla in Uremic Patients

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Abstract

In this study, we have found a reduced binding of monoclonal antibodies (CD42b and CD41a) to glycoproteins lb and Ilb/IIIa of uremic platelets. Presumably, this was due to the altered structure of the sugary part of these glycoproteins. Change in the glycoprotein composition may have effected the disturbed adhesion and aggregation of uremic platelets.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1997

Publication date (Print): 1997

Publication date (Electronic): 19 December 2008

Volume: 75

Issue: 3

Pages: 283-285

Affiliations

^aDepartment of Hematology, Karol Marcinkowski University of Medical Sciences, and ^bAmbulatory Center of Hemodialysis, Poznań, Poland

Article

Publisher ID: 189550 Other ID: Nephron 1997;75:283–285

DOI: 10.1159/000189550

PubMed ID: 9069449

SO-VID: c4066463-941b-4583-9ce6-2d4e3816818a

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 30 May 1996

Page count

Pages: 3

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