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      Treatment strategies for ADHD: an evidence-based guide to select optimal treatment

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          Abstract

          <p class="first" id="d6937890e131">Attention-deficit/hyperactivity disorder (ADHD) is a common and impairing disorder affecting children, adolescents, and adults. Several treatment strategies are available that can successfully ameliorate symptoms, ranging from pharmacological to dietary interventions. Due to the increasing range of available options, an informed selection or prioritization of treatments is becoming harder for clinicians. This review aims to provide an evidence-based appraisal of the literature on ADHD treatment, supplemented by expert opinion on plausibility. We outline proposed mechanisms of action of established pharmacologic and non-pharmacologic treatments, and we review targets of novel treatments. The most relevant evidence supporting efficacy and safety of each treatment strategy is discussed. We review the individualized features of the patient that should guide the selection of treatments in a shared decision-making continuum. We provide guidance for optimizing initiation of treatment and follow-up of patients in clinical settings. </p>

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          Author and article information

          Journal
          Molecular Psychiatry
          Mol Psychiatry
          Springer Science and Business Media LLC
          1359-4184
          1476-5578
          March 2019
          June 28 2018
          March 2019
          : 24
          : 3
          : 390-408
          Article
          10.1038/s41380-018-0116-3
          29955166
          c4341c6a-9bac-4be6-9fe0-3cdb20a188ad
          © 2019

          http://www.springer.com/tdm

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