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Neutrophil extracellular traps in ischemic stroke thrombi.
Elodie Laridan
1 ,
Frederik Denorme
1 ,
Linda Desender
1 ,
Olivier François
2 ,
Tommy Andersson
2
,
3 ,
Hans Deckmyn
1 ,
Karen Vanhoorelbeke
1 ,
Simon F De Meyer
1
Aug 2017
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Abstract
Neutrophil extracellular traps (NETs) have been shown to promote thrombus formation. Little is known about the exact composition of thrombi that cause ischemic stroke. In particular, no information is yet available on the presence of NETs in cerebral occlusions. Such information is, however, essential to improve current thrombolytic therapy with tissue plasminogen activator (t-PA). This study aimed at investigating the presence of neutrophils and more specifically NETs in ischemic stroke thrombi.