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      Hemorrhoids and matrix metalloproteinases: A multicenter study on the predictive role of biomarkers.

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          Abstract

          An association between hemorrhoidal disease and matrix metalloproteinases (MMPs) has been described previously. MMPs regulate extracellular structural proteins and tissue remodeling. Neutrophil gelatinase-associated lipocalin (NGAL) is involved in the regulation of MMP activity. The aim of this work was to study the relationship between tissue immunoreactive levels of MMPs and NGAL and different stages of hemorrhoids.

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          Author and article information

          Journal
          Surgery
          Surgery
          1532-7361
          0039-6060
          Feb 2016
          : 159
          : 2
          Affiliations
          [1 ] Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy; Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy. Electronic address: rserra@unicz.it.
          [2 ] Department of Health Sciences, University of Catanzaro, Catanzaro, Italy.
          [3 ] Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy.
          [4 ] Department of Clinical Medicine and Surgery, University of Naples "Federico II," Naples, Italy.
          [5 ] Department of Dentistry and Medical and Surgical Experimental Sciences, University of Messina, Messina, Italy.
          [6 ] Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy; Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy.
          Article
          S0039-6060(15)00541-3
          10.1016/j.surg.2015.07.003
          26263832
          c4586605-974a-436c-86e2-20c5956170c3
          Copyright © 2016 Elsevier Inc. All rights reserved.
          History

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