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Abstract
Mitophagy refers to the process of selective removal of damaged or superfluous mitochondria
via the autophagy/lysosome pathway. In the past decade the molecular mechanisms underlying
mitophagy have been extensively studied. It is now well established that the key mitophagy
machinery undergoes extensive post-translational modifications (PTMs) such as phosphorylation/dephosphorylation,
ubiquitination/deubiquitination, and acetylation/deacetylation that involve an array
of enzymes including protein kinases/phosphatases, E3 ligases/deubiquitinases, acetyltransferases/deacetylases.
In this review we provide a systematic summary of these key PTMs, and discuss the
effectors and the functional implications of such PTMs in mitophagy-related diseases.
Understanding PTM of the mitophagy machinery offers a unique window of opportunity
for the discovery of novel mitophagy interventional strategies and for the control
of mitophagy-related diseases.