Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial.

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Abstract

To evaluate the safety and tolerability of the intravenous administration of Cx611, a preparation of allogeneic expanded adipose-derived stem cells (eASCs), in patients with refractory rheumatoid arthritis (RA), as well as to obtain preliminary clinical efficacy data in this population.

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Author and article information

Journal

Journal ID (iso-abbrev): Ann. Rheum. Dis.

Title: Annals of the rheumatic diseases

Publisher: BMJ

ISSN (Electronic): 1468-2060

ISSN (Print): 0003-4967

Publication date (Electronic): Jan 2017

Volume: 76

Issue: 1

Affiliations

[1 ] Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain.

[2 ] Hospital Universitario Clínico San Carlos de Madrid, Madrid, Spain.

[3 ] Hospital General Universitario Gregorio Marañón, Madrid, Spain.

[4 ] Hospital de Cruces, Bilbao, Spain.

[5 ] Hospital Vall d'Hebron, Barcelona, Spain.

[6 ] INIBIC-Complejo Hospitalario Universitario A Coruña, A Coruña, Spain.

[7 ] Hospital Universitario Marqués de Valdecilla, Santander, Spain.

[8 ] Facultad de Medicina, Universidad de Cantabria, Santander, Spain.

[9 ] Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

[10 ] IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain.

[11 ] TiGenix, Madrid, Spain.

[12 ] Department of Medicine, Universidad de La Laguna, La Laguna, Spain.

[13 ] Complejo Hospitalario Universitario de Canarias, Tenerife, Spain.

Article

Publisher Item ID: annrheumdis-2015-208918

DOI: 10.1136/annrheumdis-2015-208918

PubMed ID: 27269294

SO-VID: c48cce07-9a9b-4662-a01f-5820eadeee04

History

Keywords: B cells,Rheumatoid Arthritis,T Cells,Treatment

Data availability:

Keywords: B cells, Rheumatoid Arthritis, T Cells, Treatment

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