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      Responses to drugs of abuse and non-drug rewards in leptin deficient ob/ob mice.

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          Abstract

          Although leptin receptors are found in hypothalamic nuclei classically associated with homeostatic feeding mechanisms, they are also present in brain regions known to regulate hedonic-based feeding, natural reward processing, and responses to drugs of abuse. The ob/ob mouse is deficient in leptin signaling, and previous work has found altered mesolimbic dopamine signaling and sensitivity to the locomotor activating effects of amphetamine in these mice.

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          Author and article information

          Journal
          Psychopharmacology (Berl.)
          Psychopharmacology
          Springer Nature America, Inc
          1432-2072
          0033-3158
          July 2016
          : 233
          : 14
          Affiliations
          [1 ] Neuroscience Research Center and Department of Pharmacology & Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
          [2 ] Neuroscience Research Center and Department of Pharmacology & Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA. colsen@mcw.edu.
          10.1007/s00213-016-4323-9 NIHMS792804
          10.1007/s00213-016-4323-9
          5095929
          27256358

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