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      Genome-wide allele-specific analysis: insights into regulatory variation.

      Nature reviews. Genetics

      Transcriptional Activation, Tissue Distribution, Quantitative Trait Loci, Polymorphism, Single Nucleotide, Polymorphism, Genetic, trends, Oligonucleotide Array Sequence Analysis, Humans, Genomics, Genome-Wide Association Study, genetics, Disease, Chromatin, Alleles

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          Abstract

          Functional genomics is rapidly progressing towards the elucidation of elements that are crucial for the cis-regulatory control of gene expression, and population-based studies of disease and gene expression traits are yielding widespread evidence of the influence of non-coding variants on trait variance. Recently, genome-wide allele-specific approaches that harness high-throughput sequencing technology have started to allow direct evaluation of how these cis-regulatory polymorphisms control gene expression and affect chromatin states. The emerging data is providing exciting opportunities for comprehensive characterization of the allele-specific events that govern human gene regulation.

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          Journal
          20567245
          10.1038/nrg2815

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