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      Early life infection, but not breastfeeding, predicts adult blood telomere lengths in the Philippines : EISENBERG ET AL.

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          Abstract

          Telomeres are repetitive DNA at chromosomes ends that shorten with age due to cellular replication and oxidative stress. As telomeres shorten, this can eventually place limits on cell replication and contribute to senescence. Infections are common during early development and activate cellular immune responses that involve clonal expansion and oxidative stress. As such, a high infectious disease burden might shorten blood telomere length (BTL) and accelerate the pace of immune senescence.

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          Demography. Broken limits to life expectancy.

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            Multiple imputation using chained equations: Issues and guidance for practice

            Multiple imputation by chained equations is a flexible and practical approach to handling missing data. We describe the principles of the method and show how to impute categorical and quantitative variables, including skewed variables. We give guidance on how to specify the imputation model and how many imputations are needed. We describe the practical analysis of multiply imputed data, including model building and model checking. We stress the limitations of the method and discuss the possible pitfalls. We illustrate the ideas using a data set in mental health, giving Stata code fragments. 2010 John Wiley & Sons, Ltd.
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              Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology.

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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                American Journal of Human Biology
                Am J Hum Biol
                Wiley
                10420533
                January 2017
                January 2017
                January 25 2017
                : e22962
                Affiliations
                [1 ]Department of Anthropology; University of Washington
                [2 ]Center for Studies in Demography and Ecology; University of Washington
                [3 ]USC-Office of Population Studies Foundation; University of San Carlos; Cebu City Philippines
                [4 ]Department of Nutrition and Dietetics; University of San Carlos; Cebu City Philippines
                [5 ]Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine; Northwestern University Feinberg School of Medicine; Chicago Illinois
                [6 ]Center for Genetic Medicine; Northwestern University Feinberg School of Medicine; Chicago Illinois
                [7 ]Department of Anthropology; Northwestern University; Evanston Illinois
                [8 ]Institute for Policy Research; Northwestern University; Evanston Illinois
                Article
                10.1002/ajhb.22962
                5511763
                28121388
                © 2017

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