Granulocyte Adherence in Uremia and Hemodialysis

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Abstract

To evaluate granulocyte function in uremia and hemodialysis we studied granulocyte adherence, an important step in chemotaxis. Our studies demonstrate that patients with severe impairment in renal function had normal granulocyte adherence (72.1 ± 21 vs. 72.9 ± 14% controls) while patients with end stage renal disease undergoing hemodialysis (45 ± 30%) had significant impairment (p < 0.001). Adherence worsened during dialysis (p < 0.001) but returned towards the abnormal baseline values at the end of the procedure. There was a significant correlation between adherence and potassium (r = 0.77; p < 0.05) and adherence and sodium-potassium ratio (r=-0.78; p < 0.05) before and after dialysis. Other factors such as changes in creatinine, urea nitrogen, osmolality, calcium, phosphorus or (H<sup>+</sup>) did not correlate with adherence. It is concluded that the abnormality in adherence is not the result of the basic disease process but a consequence of dialysis.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1979

Publication date (Print): 1979

Publication date (Electronic): 02 December 2008

Volume: 24

Issue: 2

Pages: 64-68

Affiliations

Medical and Research Services, San Juan Veterans Administration Center and Departments of Physiology and Medicine, University of Puerto Rico School of Medicine, San Juan, P. R.

Article

Publisher ID: 181685 Other ID: Nephron 1979;24:64–68

DOI: 10.1159/000181685

PubMed ID: 492412

SO-VID: c4a27525-7eaa-4ba2-bea7-9d537121ba9c

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 29 September 1978

Page count

Pages: 5

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