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      Coccidioidomycosis-associated Deaths, United States, 1990–2008

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          Abstract

          Coccidioidomycosis is a fungal disease that occurs throughout the Americas. It is contracted by inhaling spores, which are carried in dust. Therefore, it occurs most commonly in dry areas and in persons who work in dusty conditions (such as agricultural workers, construction workers, military personnel, and archeological site workers). A substantial number of people die of this disease each year, so researchers examined what other factors increase the risk for death. They found that risk for death was highest among men, elderly persons (>65 years), Hispanics, Native Americans, residents of California and Arizona, and those who also had HIV or other immune-suppressive conditions. Physicians should be aware of which patients are at increased risk and should ask patients about their travel history or occupation to determine possible sources of exposure.

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          Most cited references27

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          Epidemiology of invasive mycoses in North America.

          The incidence of invasive mycoses is increasing, especially among patients who are immunocompromised or hospitalized with serious underlying diseases. Such infections may be broken into two broad categories: opportunistic and endemic. The most important agents of the opportunistic mycoses are Candida spp., Cryptococcus neoformans, Pneumocystis jirovecii, and Aspergillus spp. (although the list of potential pathogens is ever expanding); while the most commonly encountered endemic mycoses are due to Histoplasma capsulatum, Coccidioides immitis/posadasii, and Blastomyces dermatitidis. This review discusses the epidemiologic profiles of these invasive mycoses in North America, as well as risk factors for infection, and the pathogens' antifungal susceptibility.
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            Coccidioidomycosis.

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              Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997.

              To determine national trends in mortality due to invasive mycoses, we analyzed National Center for Health Statistics multiple-cause-of-death record tapes for the years 1980 through 1997, with use of their specific codes in the International Classification of Diseases, Ninth Revision (ICD-9 codes 112.4-118 and 136.3). In the United States, of deaths in which an infectious disease was the underlying cause, those due to mycoses increased from the tenth most common in 1980 to the seventh most common in 1997. From 1980 through 1997, the annual number of deaths in which an invasive mycosis was listed on the death certificate (multiple-cause [MC] mortality) increased from 1557 to 6534. In addition, rates of MC mortality for the different mycoses varied markedly according to human immunodeficiency virus (HIV) status but were consistently higher among males, blacks, and persons > or =65 years of age. These data highlight the public health importance of mycotic diseases and emphasize the need for continuing surveillance.
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                Author and article information

                Journal
                Emerg Infect Dis
                Emerging Infect. Dis
                EID
                Emerging Infectious Diseases
                Centers for Disease Control and Prevention
                1080-6040
                1080-6059
                November 2012
                : 18
                : 11
                : 1723-1728
                Affiliations
                [-1-1]Keck School of Medicine of University of Southern California, Los Angeles, California, USA (J.Y. Huang);
                [-1-2]and University of California Los Angeles Fielding School of Public Health, Los Angeles (B. Bristow, S. Shafir, F. Sorvillo)
                [-2-1]Keck School of Medicine of University of Southern California, Los Angeles, California, USA (J.Y. Huang);
                [-2-2]and University of California Los Angeles Fielding School of Public Health, Los Angeles (B. Bristow, S. Shafir, F. Sorvillo)
                [-3-1]Keck School of Medicine of University of Southern California, Los Angeles, California, USA (J.Y. Huang);
                [-3-2]and University of California Los Angeles Fielding School of Public Health, Los Angeles (B. Bristow, S. Shafir, F. Sorvillo)
                Author notes
                Address for correspondence: Frank Sorvillo, UCLA Fielding School of Public Health, Department of Epidemiology, Box 951772, 46-070 CHS, Los Angeles, CA 90095-1772, USA; email: fsorvill@ 123456ucla.edu
                Address for correspondence: Frank Sorvillo, UCLA Fielding School of Public Health, Department of Epidemiology, Box 951772, 46-070 CHS, Los Angeles, CA 90095-1772, USA; email: fsorvill@ 123456ucla.edu
                Article
                12-0752
                10.3201/eid1811.120752
                3559166
                23092645
                c4bbf990-103d-4095-ae2d-156a83bfb4e3
                History
                Categories
                CME
                Research
                Research

                Infectious disease & Microbiology
                coccidioidomycosis,mortality,united states,fungi,deaths,coccidioides immitis,coccidioides posadasii,coccidioides spp

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