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      Sulpiride and the potentiation of progestogen only contraception.

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          Abstract

          A progestogen (norethisterone) and a dopamine antagonist (sulpiride) were given alone and in combination to volunteers to examine their effects on excretion of ovarian steroids. Compared with non-treatment cycles (n = 15), contraception with a progestogen alone (n = 10) was associated with increased excretion of oestrone and partial suppression of excretion of pregnanediol, suggesting partial luteinization of unruptured follicles. By contrast, the combination of norethisterone and sulpiride (n = 9) suppressed both ovarian steroids to basal values, the suppression being even greater than with sulpiride alone (n = 5). These results suggest that a combination of a progestogen with a dopamine antagonist might have a role in contraception.

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          Author and article information

          Journal
          Br Med J (Clin Res Ed)
          British medical journal (Clinical research ed.)
          BMJ
          0267-0623
          0267-0623
          Aug 31 1985
          : 291
          : 6495
          Article
          10.1136/bmj.291.6495.559
          1418199
          2994800
          c4c3af39-58ef-45ca-bfec-98628745cd6e
          History

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