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      Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease

      , , , , , , , , ,
      Journal of Neuroimmunology
      Elsevier BV

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          Abstract

          We studied an autoantibody (called anti-Tr), found in the serum and CSF of five patients with paraneoplastic cerebellar degeneration (PCD) and Hodgkin's disease (HD). Anti-Tr antibodies labelled the cytoplasm of Purkinje cells of human and rat cerebellum. The molecular layer of rat cerebellum showed a characteristic dotted pattern suggestive of immunoreactivity of dendritic spines of Purkinje cells. Patients with cerebellar disorders without HD (159) or HD without PCD (30) did not harbor anti-Tr antibodies. Immunoblots of human Purkinje cells or rat and mouse cerebellum were negative. Anti-Tr antibodies, as defined in this study, appear specific for HD-associated PCD. The immunohistochemical pattern described in the rat cerebellum coupled with the absence of reactivity in the immunoblot may be used to identify anti-Tr antibodies.

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          Author and article information

          Journal
          Journal of Neuroimmunology
          Journal of Neuroimmunology
          Elsevier BV
          01655728
          April 1997
          April 1997
          : 74
          : 1-2
          : 55-61
          Article
          10.1016/S0165-5728(96)00205-6
          9119979
          c4f8d592-3632-4a50-9d9e-e9a95949c32e
          © 1997

          https://www.elsevier.com/tdm/userlicense/1.0/

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