8
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Lyotropic Liquid Crystalline Nanostructures as Drug Delivery Systems and Vaccine Platforms.

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Lyotropic liquid crystals result from the self-assembly process of amphiphilic molecules, such as lipids, into water, being organized in different mesophases. The non-lamellar formed mesophases, such as bicontinuous cubic (cubosomes) and inverse hexagonal (hexosomes), attract great scientific interest in the field of pharmaceutical nanotechnology. In the present review, an overview of the engineering and characterization of non-lamellar lyotropic liquid crystalline nanosystems (LLCN) is provided, focusing on their advantages as drug delivery nanocarriers and innovative vaccine platforms. It is described that non-lamellar LLCN can be utilized as drug delivery nanosystems, as well as for protein, peptide, and nucleic acid delivery. They exhibit major advantages, including stimuli-responsive properties for the "on demand" drug release delivery and the ability for controlled release by manipulating their internal conformation properties and their administration by different routes. Moreover, non-lamellar LLCN exhibit unique adjuvant properties to activate the immune system, being ideal for the development of novel vaccines. This review outlines the recent advances in lipid-based liquid crystalline technology and highlights the unique features of such systems, with a hopeful scope to contribute to the rational design of future nanosystems.

          Related collections

          Author and article information

          Journal
          Pharmaceuticals (Basel)
          Pharmaceuticals (Basel, Switzerland)
          MDPI AG
          1424-8247
          1424-8247
          Mar 31 2022
          : 15
          : 4
          Affiliations
          [1 ] Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.
          [2 ] Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.
          [3 ] Uni-Pharma S.A., 14564 Kifissia, Greece.
          Article
          ph15040429
          10.3390/ph15040429
          9028109
          35455426
          c505608f-ec2b-4501-ba54-e7fbb0c96236
          History

          vaccines,stimuli-responsive,lyotropic liquid crystals,lipid nanoparticles,drug delivery nanosystems,cubosomes,controlled drug release

          Comments

          Comment on this article